Kind code of ref document : A1. Designated state s : JP US. Ref document number : Country of ref document : EP. Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet. DE DET2 de

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Biosensors are analytical devices which incorporate a biological component enzyme, antibody, animal or plant cell, DNA fragments, lipids… intimately connected to a physical transducer electrode, optical fibre, vibrating quartz…. This dual configuration allows the study of a great variety of compounds of pharmaceutical interest which react with the biocomponent.

The latter is selected depending on the application and the performance criteria requested. Biosensors are suitable for real time monitoring such as in bioreactors, and for the determination of various physiological and pharmacological parameters. Biosensors may be employed in home testing glucose, lactate… , in hospitals bedside testing, emergency, surgery, dialysis monitoring, etc… in clinical laboratory analyses immunoassays, DNA analysis… and at research centres.

Ideally, a biosensor should be easy to use, allowing direct analysis without sample pre-treatment. Measurements shoud be automatized and remote controlled.

The biosensor may be miniaturized for single use or for implementation in sensor arrays. Applications to microenvironments in vivo , single cell… or discrete one shot decentralized tests may also considered.

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