GRANULOMA EOSINOFILICO PDF

Spontaneous remission of an orbital eosinophilic granuloma after biopsy - A case report and literature review. The histopathological study showed a granuloma with a proliferative aspect with macrophages, eosinophils and Langerhans' cells, without neoplastic features. After biopsy there was spontaneous remission demonstrated by computerized tomography scans of the orbit on a month follow-up period. Lichtenstein L. Histiocytosis X: integration of eosinophilic granuloma of bone, Letterer-Siwe disease and Shuller-Christian disease as a single nosologic entity. Arch Pathol ;

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The term eosinophilic granuloma complex EGC refers to a group of inflammatory skin problems in cats. Different clinical forms of the disease are recognised, although the underlying inflammatory response often appears very similar. The skin lesions are often highly pruritic itchy and can be exacerbated by the cat licking them. The lesions of EGC have to be differentiated from other skin diseases such as: fungal, bacterial or viral infections; skin or oral tumours; abscesses; and other causes of swellings.

To confirm the diagnosis and rule out other causes, microscopic examination of tissues cytology of a needle aspirate or preferably a biopsy is required. Histological examination of tissue by a pathologist will typically show inflammation and ulceration and the presence of a large number of eosinophils a type of inflammatory cell often associated with allergic reactions.

The histological appearance is quite typical for EGC, although differentiating between the different forms of EGC can be difficult and is not really necessary. When an EGC lesion is diagnosed, it is important to search for possible underlying causes, especially potential underlying allergies.

Your vet will probably want to evaluate your cat carefully for common potential allergies such as flea bite allergy, mosquito bite allergy and food allergy. These investigations may include response to trial treatments or food trials. Trial treatments for flea eradication or food trials using a special diet may take time e. Some cases of EGC may be associated with atopy reaction to environmental or inhaled allergens , and these may be more difficult to investigate and manage.

Although there is no evidence that bacteria actually cause EGC lesions in cats, it is very common to have secondary bacterial contamination and infection of the tissues involved. Where this is the case, a course of antibiotics may help the the condition, and in some cases this can produce quite a dramatic improvement although it will not resolve the lesion. Treatment depends on the extent of the problem and trying to find the underlying cause of the reaction see above.

If no underlying cause is evident, or if an underlying cause is identified but cannot be controlled, symptomatic treatment of the lesions may be required. Small single lesions which do not seem to bother the cat may be left, and some of these will spontaneously resolve. If disease is more extensive, treatment will be required. Glucocorticoids steroids are the most common form of therapy usually given as tablets, oral liquid, or injection , and in many cases the lesions respond very well and pruritus will rapidly subside.

The duration and dose of steroids needed will vary between cats, but in some recurrent treatment or continuous therapy may be needed to control the disease. If long-term or high doses of steroids are needed, additional or alternative therapies may also be tried to help reduce the dose of steroids needed to help minimise the risk of long-term side effects.

Other treatments include:. In the past, progestagens progesterone-like drugs such as megoestrol acetate, and medroxyprogesterone acetate have been used to treat EGCs. However, these drugs work because they have extremely potent glucocorticoid steroid -like activity and they have a high frequency of significant side effects. All our advice is freely accessible to everyone, wherever you are in the world. However, as a charity, we need your support to enable us to keep delivering high quality and up to date information for everyone.

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Click Yes to help us continue to make these improvements. Our Other Sites Close. Our Other Sites. The lip develops a clearly demarcated ulcer that can have a raised border and there may be marked swelling of the lip in the region of the ulcerated area. The ulcer can get large and very extensive in some severe cases.

They usually appear as well demarcated, flat swellings of the skin with a reddened appearance. Hair is usually lost from the affected skin and the lesions can be very pruritic itchy. Ulceration is common. The lesion appearance is variable but usually there is a nodular or linear area of raised, thickened skin that may be reddened.

Hair loss and ulceration are again common findings although pruritus may be more variable. Investigation of EGC When an EGC lesion is diagnosed, it is important to search for possible underlying causes, especially potential underlying allergies.

Treatment of EGC lesions Although there is no evidence that bacteria actually cause EGC lesions in cats, it is very common to have secondary bacterial contamination and infection of the tissues involved. Other treatments include: Anti-histamines, which may help in some cases Immunosuppressive drugs such as ciclosporin or chlorambucil Topical steroids such as hydrocortisone aceponate spray that should have minimal systemic side effects In the past, progestagens progesterone-like drugs such as megoestrol acetate, and medroxyprogesterone acetate have been used to treat EGCs.

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For a general discussion of this disease please refer to the article on Langerhans cell histiocytosis LCH. When symptomatic, patients complain of pain, swelling and tenderness around the lesion. Systemic symptoms may also be present, including general malaise and, on occasion, fever with leukocytosis. There is proliferation of Langerhans cells with an abundance of eosinophils, lymphocytes and neutrophils. These cells produce prostaglandins which result in medullary bone resorption: this is what causes the symptoms. The most common locations are the skull and long bones 5,6 :. Similar to plain film findings with better demonstration of cortical erosion and soft tissue involvement.

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Eosinophilic Granuloma

The term eosinophilic granuloma complex EGC refers to a group of inflammatory skin problems in cats. Different clinical forms of the disease are recognised, although the underlying inflammatory response often appears very similar. The skin lesions are often highly pruritic itchy and can be exacerbated by the cat licking them. The lesions of EGC have to be differentiated from other skin diseases such as: fungal, bacterial or viral infections; skin or oral tumours; abscesses; and other causes of swellings. To confirm the diagnosis and rule out other causes, microscopic examination of tissues cytology of a needle aspirate or preferably a biopsy is required.

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