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N Engl J Med. PMID: No abstract available. Heparin-Induced Thrombocytopenia. Klarenbeek NB, et al. Hoover J. Similar articles Argatroban, a new treatment option for heparin-induced thrombocytopenia. Cleveland KW. Crit Care Nurse. PMID: Review. No abstract available. Management of patients with heparin-induced thrombocytopenia: focus on recombinant hirudin. Lubenow N, Greinacher A. Lubenow N, et al. J Thromb Thrombolysis. Hitting back HIT. Gude D. Ann Card Anaesth.
Heparin-induced thrombocytopenia: what clinicians need to know. Chong BH, Isaacs A. Chong BH, et al. Thromb Haemost. Nonheparin anticoagulants for heparin-induced thrombocytopenia.
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Yoshida R, et al. Eur Heart J Case Rep. Heparin-induced Thrombocytopenia: Pathophysiology, Diagnosis and Management. Patriarcheas V, et al. How to measure blood pressure using an arterial catheter: a systematic 5-step approach. Saugel B, et al. Crit Care. Wien Klin Mag. Epub Jan Suljevic I, et al. Med Arch. Show more "Cited by" articles See all "Cited by" articles. Publication types Review Actions. Female Actions. Humans Actions. Middle Aged Actions. Practice Guidelines as Topic Actions. Substances Anticoagulants Actions.
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Blood Apr Heparin-induced thrombocytopenia HIT , often with thrombosis, is suspected when the platelet count declines in a patient receiving heparin. Successful management depends on quickly discontinuing all sources of heparin and initiating alternative anticoagulants. However, clinical suspicion and laboratory testing are occasionally inaccurate and could result in continuing thromboses if heparin is continued or bleeding if heparin is exchanged for another anticoagulant. To improve the diagnostic strategy for HIT, investigators conducted a prospective cohort study in patients suspected of having this disorder. They observed the following:.
NEJM Journal Watch
A new Clinical Practice article provides an overview of heparin induced thrombocytopenia. Platelet factor 4—heparin antibody testing has a high negative, but low positive, predictive value. In contrast to other conditions caused by enhanced consumption, impaired production, or destruction of platelets, which lead to bleeding complications, immune-mediated heparin-induced thrombocytopenia HIT does not induce bleeding but rather results in a paradoxical prothrombotic state. HIT occurs in approximately 1 in hospitalized patients. Figure 1.
CLINICAL PRACTICE. Heparin-Induced Thrombocytopenia
In view of this, it has been apportioned its own revision chapter. This article has added credibility because is Andreas Greinacher has been publishing HITS-related material since the nineties, and is something of a guru in the field. Its not clear whether it was posted in this way intentionally. Apparently in a consensus statement of representatives from three research groups Greinacher was one of them had finally nailed down some sort of laboratory definition, but this statement is not available anywhere. In summary:.