Clarifying the role of AML1-ETO in leukemogenesis has been difficult because the expression of the oncoprotein is not sufficient to cause disease. The earliest attempts to model AML1-ETO-associated leukemia in mice showed that the oncoprotein has detrimental developmental effects when expressed during embryogenesis 2 , 3. Transgenic models, inducible systems, and bone marrow transplant strategies for expressing AML1-ETO were unable to reliably produce leukemia in mice even after 24 months 4 — 7. However, the failure to cause leukemia was extremely enlightening. When stem cells were transduced with AML1-ETO and transplanted into lethally irradiated recipient animals, the stem cell compartment expanded dramatically 6. The requirement for cooperating events is not surprising in hindsight.
|Published (Last):||14 November 2011|
|PDF File Size:||10.93 Mb|
|ePub File Size:||18.73 Mb|
|Price:||Free* [*Free Regsitration Required]|
Login or register free and only takes a few minutes to participate in this question. You will also have access to many other tools and opportunities designed for those who have language-related jobs or are passionate about them.
Participation is free and the site has a strict confidentiality policy. The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.
You can request verification for native languages by completing a simple application that takes only a couple of minutes. Review native language verification applications submitted by your peers.
Reviewing applications can be fun and only takes a few minutes. KudoZ activity Questions: 8 open closed without grading Answers: Grading comment Thanks again, Charles.
Discussion entries: 1. Automatic update in Return to KudoZ list. You have native languages that can be verified You can request verification for native languages by completing a simple application that takes only a couple of minutes.
View applications. Close and don't show again Close. Close search. Term search Jobs Translators Clients Forums. Term search All of ProZ. Spanish term or phrase:. Joseph Tein. I'm proofreading a translation of a very technical to me, at least document that discusses the rights of subjects in clinical trials. FDA are clearly lawyers and they're lacing the document with legal language. Not my usual medical terminology!
Thanks for your help! Local time: Explanation: Hi Joseph; me again. It is a ruling "sobre amparo". The case mentioned in your document is a fundamental one in the field of health and right to life, by the way. You can put "on appeal", but it really isn't correct, because although the term "recurso de amparo" suggests a kind of appeal and in a broad sense it is , it is certainly not what "appeal" normally means in English, and would be misleading.
Versions such as "appeal for legal protection" have been suggested, but this is a little imprecise. To be accurate, I think you'd have to say "petition for protection of constitutional rights".
But it's quite standard just to leave it as "amparo". Selected response from: Charles Davis Spain Local time: Charles Davis. Marjory Hord Mexico. Notes to answerer Asker: I see that it's you again I've been turning this "amparo" term around in my head for years without coming up with any meaning that makes sense to me in English.
Thanks for shedding some light on it. Login to enter a peer comment or grade.
Class/collective actions in Argentina: overview
Ecuador - - Acuerdo internacional. Dado en Quito. Egipto - - Ley. Law No. Part I: Definitions.
Fallo: "Halabi, Ernesto c/ P.E.N. - ley 25.873 - dto. 1563/04 s/ amparo ley 16.986".
Something went wrong. Please try your request again later. Are you an author? Help us improve our Author Pages by updating your bibliography and submitting a new or current image and biography. Learn more at Author Central. Previous page.
Fusion-protein truncation provides new insights into leukemogenesis
This resource is periodically updated for necessary changes due to legal, market, or practice developments. Significant developments affecting this resource will be described below. Ask a question. Related Content. Are they popular and what are the current trends? The recognition of such actions has increased since the constitutional reform of , which suggested that consumer associations and the protection of their collective rights was needed.