Aka: Polyarteritis Nodosa. These images are a random sampling from a Bing search on the term "Polyarteritis Nodosa. Search Bing for all related images. Started in , this collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters. Content is updated monthly with systematic literature reviews and conferences.

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This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly.

If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease.

You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.

They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care. You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists. Research helps us better understand diseases and can lead to advances in diagnosis and treatment.

This section provides resources to help you learn about medical research and ways to get involved. Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services.

Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Inclusion on this list is not an endorsement by GARD. These resources provide more information about this condition or associated symptoms.

The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional. Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know.

Submit a new question. How does this disease affect the gastrointestinal tract? What are the causes of this disease? Does it have anything to do with collagen? How rare is it? See answer. What is the estimated rate of recurrence for this condition? What is the life expectancy for people with this condition? How can I find information on treatment for polyarteritis nodosa?

Are there any dietary supplements or other alternative therapies that have been used to treat polyarteritis nodosa?

National Institutes of Health. COVID is an emerging, rapidly evolving situation. Menu Search Home Diseases Polyarteritis nodosa. You can help advance rare disease research! Title Other Names:. PAN; Periarteritis; Polyarteritis. Summary Summary. Symptoms Symptoms. Showing of 21 View All. Abnormal kidney. Joint pain.

Muscle ache. Muscle pain. Pain in stomach. Stomach pain. Swelling or irritation of membrane around heart. Open skin sore. Firm lump under the skin. Growth of abnormal tissue under the skin. Abnormal eye. Disease of the heart muscle. Inflammation of tissues lining lungs and chest. Do you have more information about symptoms of this disease?

We want to hear from you. Cause Cause. The exact cause of polyarteritis nodosa PAN is not known, and in most cases, no predisposing cause has been found it is idiopathic. Many scientists believe that it is an autoimmune disease. Research has suggested that an abnormal immune response to an initial infection may trigger the development of PAN. It has also appeared to occur as an allergic reaction to some drugs and vaccines. Thickening of the walls of affected vessels causes narrowing of the inside of the vessels, reducing blood flow and predisposing to blood clots in affected vessels.

Treatment Treatment. There is no cure for polyarteritis nodosa PAN , but the disease and its symptoms can be managed. The goal of treatment is to prevent disease progression and further organ damage. For severe disease with these symptoms, cyclophosphamide may also be used.

Hypertension should be treated aggressively. Prognosis Prognosis. We could not find a description of the average life expectancy for individuals with polyarteritis nodosa. However, one study examined the overall mortality of a group of individuals with this condition. Mortality is a measure of the proportion of individuals in a group who die in a given time period. Factors which increased the risk of death included being older than 65 years, being recently diagnosed with high blood pressure hypertension , or having gastrointestinal symptoms that required surgery at the time of diagnosis for example, abdominal pain, internal bleeding, pancreatitis , cholecystitis , appendicitis.

Statistics Statistics. Polyarteritis nodosa PAN is a rare disease, with an incidence of about 3 to 4. Internationally, the annual estimated incidence of PAN ranges from 1. While it has been diagnosed in people of every age, it predominantly occurs in people between the ages of years. Do you have updated information on this disease? Find a Specialist Find a Specialist. Research Research. Clinical Research Resources ClinicalTrials. Click on the link to go to ClinicalTrials. We strongly recommend that you talk with a trusted healthcare provider before choosing to participate in any clinical study.

Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query". Patient Registry The Autoimmune Registry supports research for Polyarteritis nodosa by collecting information about patients with this and other autoimmune diseases. You can join the registry to share your information with researchers and receive updates about participating in new research studies.

Learn more about registries. The Vasculitis Clinical Research Consortium VCRC is an integrated group of academic medical centers, patient support organizations, and clinical research resources dedicated to conducting clinical research in different forms of vasculitis.

Organizations Organizations. Organizations Supporting this Disease. Vasculitis Foundation P. Organizations Providing General Support.

Do you know of an organization? Learn More Learn More. MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.


Polyarteritis Nodosa

Polyarteritis nodosa PAN is a condition that causes swollen arteries. It primarily affects small and medium arteries, which can become inflamed or damaged. This is a serious disease of the blood vessels caused by an immune system malfunction. PAN ultimately affects all of your organs, including the skin. It can also affect your central nervous system. Without medical treatment, PAN can cause seizures and neurological issues, including reduced alertness and cognitive dysfunction, after two to three years. Skin lesions are also very common.


Polyarteritis nodosa

Polyarteritis nodosa PAN , is a systemic necrotizing inflammation of blood vessels vasculitis affecting medium-sized muscular arteries , typically involving the arteries of the kidneys and other internal organs but generally sparing the lungs' circulation. PAN is a rare disease. Death is often a consequence of kidney failure , myocardial infarction , or stroke. PAN may affect nearly every organ system and thus it can present with a broad array of signs and symptoms.


This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease.

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