FRMACOS ANTIVIRAIS PDF

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HIV: replication mechanism, pharmacological targets and inhibition by products derived from plants. The AIDS epidemy has spread out and led to the diversification on the research for new antiviral drugs. Natural products, especially those derived from plants, are well-recognized as excellent sources of new drugs. Several of them have inhibitory activity against HIV replication, and some have been already clinically tested, with favorable results.

This review presents the biochemical basis of the viral cycle and the research up to date on the identification, determination of the mechanism of biological action together with the therapeutical potential of plants-derived natural products, in the inhibition of HIV.

Keywords: HIV; natural products; antiviral. Toda esta morbi-mortalidade estimulou o desenvolvimento de terapias antirretrovirais. Outras atividades anti-HIV de produtos naturais. A 1,4-fenantrenoquinona denbinobina 16 , foi isolada de uma variedade de Cannabis sativa. Vaishnav, Y. Campbell, R. Adamson, C. Today , 13 , Hardman, J. Aiken, C. Turriziani, O. Agents Chemother. Cos, P. Calderone, V. HIV Res. Lam, T. Manganelli, R.

Fujioka, T. Cunico, W. Nova , 31, Yang, S. De Souza, M. Nova , 26, Saklani, A. Today , 13, Gulick, R. Internal Med. De Albuquerque, U. De Lima, M. F; De Paula, J. Brooks, G. Frankel, A.

Clements, J. Ali, A. Methods , , Chaudhry, A. Hussain, A. Nova , 25 , Sierra, S. Yang, X. Suzuki, Y. Ciuffi, A. Vlietinck, A. Dias, K. Duarte D. Mukhtar, M. Ayisi, N. Tilton, J. Bedoya, L. Notka, F. Wang, L.

Patil, A. De Melo, E. Nova , 29, Reinke, R. Gray, D. Bessong, P. Wang, X. Matsuse, I. Pu, J. Okano, M. Smith, P. Li, F. Itokawa, H. Williamson, M. Allergy Clin. Nance, C. Tian, R. Bokesch, H. Chang, Y. Wang, R. Woradulayapinij, W. Klos, M. Harnett, S. Lam, S. Huerta-Reyes, M. Ali, H. Tshikalange, T. Botany , 74 , Min, B. Fang, E. Kitamura, K. Kim, H. Tewtrakul, S. Lee, J. Wei, Y. Cheenpracha, S. Balzarini, J.

Wu, J. Lee, T. Hsieh, P. Duan, H. Yu, D. McKee, T.

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